SELECTED Publications
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Live imaging endogenous transcription factor dynamics reveals mechanisms of epiblast and primitive endoderm segregation
Kim-Yip RP*, Denberg D*, Faerberg DF, Nunley H, Leite I, Chalifoux M, Joyce B, Toettcher J, Gu B, Posfai E ✉ Current Biology (2025) doi: 10.1016/j.cub.2025.07.031 *equal contribution |
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Epithelial polarization by the planar cell polarity complex is exclusively non-cell autonomous
Basta L, Joyce B, Posfai E, Devenport D ✉ Science (2025) doi: 10.1126/science.ads5704 |
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Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development
Madeleine Chalifoux*, Avdeeva M*, Posfai E ✉ Developmental Biology (2025) doi: https://doi.org/10.1101/2025.02.27.640568 *equal contribution |
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Generative model for the first cell fate bifurcation in mammalian development
Avdeeva M*✉, Madeleine Chalifoux*, Bradley Joyce, Shvartsman S, Posfai E ✉ bioRxiv (2025) doi: https://doi.org/10.1101/2025.02.24.639895 accepted in Development *equal contribution |
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A tug-of-war between germ cell motility and intercellular bridges controls germline cyst formation in mice
Levy E*, Leite I*, Joyce B, Shvartsman S, Posfai E ✉ Current Biology (2024) https://doi.org/10.1016/j.cub.2024.10.062 *equal contribution |
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Efficient prime editing in two-cell mouse embryos using PEmbryo Kim-Yip R*, McNulty R*, Joyce B, Mollica A, Chen P, Ravisankar P, Law B, Liu D, Toettcher J, Ivakine E, Posfai E ✉, Adamson B ✉ Nature Biotechnology (2024) https://doi.org/10.1038/s41587-023-02106-x *equal contribution |
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Nuclear instance segmentation and tracking for preimplantation mouse embryos
Nunley H, Shao B, Denberg D, Grover P, Singh J, Avdeeva M, Joyce B, Kim-Yip R, Kohrman A, Biswas A, Watters A, Gal Z, Kickuth A, Chalifoux M, Shvartsman S, Brown L ✉, Posfai E ✉ Development (2024) https://doi.org/10.1242/dev.202817 |
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New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo
Basta L, Hill-Oliva M, Paramore S.V., Sharan R, Goh A, Biswas W, Cortez M, Little K, Posfai E, Devenport D ✉ Development (2021) 148(18):dev199695. |
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All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models
Posfai E ✉, Lanner F ✉, Mulas C, Leitch HG ✉ Stem Cell Reports (2021) 16(5):1117-1141. Review. |
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Imaging developmental cell cycles Kohrman AQ, Kim-Yip RP, Posfai E ✉ Biophys J. (2021) 120(19):4149-4161. Review. |
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Evaluating totipotency using criteria of increasing stringency Posfai E ✉, Schell JP, Janiszewski A, Rovic I, Murray A, Bradshaw B, Yamakawa T, Pardon T, El Bakkali M, Talon I, De Geest N, Kumar P, To SK, Petropoulos S, Jurisicova A, Pasque V ✉, Lanner F ✉, Rossant J ✉ Nature Cell Biology (2021) 23(1):49-60 |
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Efficient Generation of Large-Fragment Knock-In Mouse Models Using 2-Cell (2C)-Homologous Recombination (HR)-CRISPR Gu B, Posfai E, Gertsenstein M, Rossant J ✉ Current Protocols in Mouse Biology (2020) 10(1):e67 |
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Generation of Large-Fragment Knock-In Mouse Models by Microinjecting into 2-Cell Stage Embryos
Gu B ✉, Gertsenstein M, Posfai E Methods in Molecular Biology (2020) 2066:89-100 |
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Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos Okamura E, Tam OH, Posfai E, Li L, Cockburn K, Lee CQE, Garner J, Rossant J ✉ Developmental Biology (2019) 455(2):382-392 |
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The mammalian embryo's first agenda: making trophectoderm
Posfai E ✉, Rovic I, Jurisicova A ✉ The International Journal of Developmental Biology (2019) 63(3-4-5):157-170 |
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Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos Gu B*, Posfai E*, Rossant J ✉ Nature Biotechnology (2018) 36(7):632-637 *equal contribution |
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Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions
Yachie-Kinoshita A, Onishi K, Ostblom J, Langley M, Posfai E, Rossant J, Zandstra PW ✉ Molecular Systems Biology (2018) 14(1): e7952 |
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Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo Posfai E, Petropoulos S, de Barros FRO, Schell JP, Jurisica I, Sandberg R, Lanner F, Rossant J ✉ eLife (2017) 6:e22906 |
Depending on maternal Yap
Posfai E, Rossant J
Cell Research (2016) 26: 393–394. Research highlight.
Posfai E, Rossant J
Cell Research (2016) 26: 393–394. Research highlight.
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Mechanisms of pluripotency in vivo and in vitro Posfai E, Tam OH, Rossant J ✉ Current Topics in Developmental Biology (2014) 107: 1-37. Review. |
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Polycomb function during oogenesis is required for early embryonic development
Posfai E, Kunzmann R, Brochard V, Salvaing J, Cabuy E, Roloff T-C, Liu Z, Tardat M, van Lohuizen M, Vidal M, Beaujean and Antoine HFM Peters ✉ Genes and Development (2012) 26(9): 920-32 |
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BspRI restriction endonuclease: cloning, expression in E. coli and sequential cleavage mechanism Raskó T, Dér, A, Klement É, Ślaska-Kiss K, Pósfai E, Medzihradszky K, Marshak D, Roberts R, Kiss A ✉ Nucleic Acids Research (2010) 38(20): 7155-7166 |
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Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation van der Heijden GW*, Derijck AA*, Posfai E, Giele M, Pelczar P, Ramos L, Wansink DG, van der Vlag J, Peters AHFM, de Boer P ✉ Nature Genetics (2007) 39(2): 251-8 *equal contribution |